Major studies of the use of statins before noncardiac surgery
نویسنده
چکیده
■ ■ Preliminary evidence indicates that statin drugs may be beneficial when given in the perioperative period. Although more studies are needed to draw firm conclusions, the acute nonlipid pleiotropic effects of statins may improve patient outcomes, especially for patients at the highest risk.
منابع مشابه
Delirium after elective surgery among elderly patients taking statins.
BACKGROUND Postoperative delirium after elective surgery is frequent and potentially serious. We sought to determine whether the use of statin medications was associated with a higher risk of postoperative delirium than other medications that do not alter microvascular autoregulation. METHODS We conducted a retrospective cohort analysis of 284 158 consecutive patients in Ontario aged 65 years...
متن کاملSurveillance and prevention of major perioperative ischemic cardiac events in patients undergoing noncardiac surgery: a review.
This is the second of 2 articles evaluating cardiac events in patients undergoing noncardiac surgery. Unrecognized myocardial infarctions (MIs) are common, and up to 50% of perioperative MIs may go unrecognized if physicians rely only on clinical signs or symptoms. In this article, we summarize the evidence regarding monitoring strategies for perioperative MI in patients undergoing noncardiac s...
متن کاملStatins decrease perioperative cardiac complications in patients undergoing noncardiac vascular surgery: the Statins for Risk Reduction in Surgery (StaRRS) study.
OBJECTIVES We sought to assess whether statins may decrease cardiac complications in patients undergoing noncardiac vascular surgery. BACKGROUND Cardiovascular complications account for considerable morbidity in patients undergoing noncardiac surgery. Statins decrease cardiac morbidity and mortality in patients with coronary disease, and the beneficial treatment effect is seen early, before a...
متن کاملStatins are associated with a reduced incidence of perioperative mortality in patients undergoing major noncardiac vascular surgery.
BACKGROUND Patients undergoing major vascular surgery are at increased risk of perioperative mortality due to underlying coronary artery disease. Inhibitors of the 3-hydroxy-3-methylglutaryl coenzyme A (statins) may reduce perioperative mortality through the improvement of lipid profile, but also through the stabilization of coronary plaques on the vascular wall. METHODS AND RESULTS To evalua...
متن کاملStatins and incidence of perioperative mortality in patients undergoing major noncardiac vascular surgery.
in Patients Undergoing Major Noncardiac Vascular Surgery To the Editor: Poldermans et al1 published a retrospective study in which they found evidence that statin use reduces perioperative mortality in patients undergoing major vascular surgery. We have, however, some methodological concerns pertaining to selection, information, and confounding bias that were not discussed but that may have har...
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تاریخ انتشار 2008